產品櫥窗
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17-AAG
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產品型號：101-75747-14-7 商品規格： |
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Synonym: 17-(Allylamino)geldanamycin, 17-AAG, 17-Demethoxy-17-allylamino geldanamycin, CP 127374, Geldanamycin,17-demethoxy-17-(2-propenylamino)-, NSC 330507, Tanespimycin
C31H43N3O8
M.W. 585.69
Appearance: Purple Powder
Solubility: DMSO, Methanol, clear purple solution at 10 mg/ml
Purity(HPLC): > 99%
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). 17-AAG is able to disrupt the Hsp90-client protein complexes and lead to the degradation of the client proteins.
Regulated Binding of Importin-α to Protein Kinase Cin Response to Apoptotic Signals Facilitates Nuclear Import, Tariq S. Adwan, Angela M. Ohm, et al, Oct 2011; 286: 35716 - 35724.
The Dual EGFR/HER2 Inhibitor Lapatinib Synergistically Enhances the Antitumor Activity of the Histone Deacetylase Inhibitor Panobinostat in Colorectal Cancer Models, Melissa J. LaBonte, Peter M. Wilson, et al, May 2011; 71: 3635 - 3648.
Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90), Lawrence C.S. Tam, Anna-Sophia Kiang, et al, Nov 2010; 19: 4421 - 4436.
M.W. 585.69
Appearance: Purple Powder
Solubility: DMSO, Methanol, clear purple solution at 10 mg/ml
Purity(HPLC): > 99%
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). 17-AAG is able to disrupt the Hsp90-client protein complexes and lead to the degradation of the client proteins.
Regulated Binding of Importin-α to Protein Kinase Cin Response to Apoptotic Signals Facilitates Nuclear Import, Tariq S. Adwan, Angela M. Ohm, et al, Oct 2011; 286: 35716 - 35724.
The Dual EGFR/HER2 Inhibitor Lapatinib Synergistically Enhances the Antitumor Activity of the Histone Deacetylase Inhibitor Panobinostat in Colorectal Cancer Models, Melissa J. LaBonte, Peter M. Wilson, et al, May 2011; 71: 3635 - 3648.
Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90), Lawrence C.S. Tam, Anna-Sophia Kiang, et al, Nov 2010; 19: 4421 - 4436.
Store at -20℃.
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Protect from light!