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  • Hemin, >98%
  • 產品型號:101-16009-13-5

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Hemin is used in cellular protection and control mechanism. Synonyms: Hemin chloride Chloro(protoporphyrinato)iron(III)

C34H32ClFeN4O4
M.W.: 651.94

    Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders.

    Hemin may be used to study the expression and represson of heme oxygenase 1 (HO-1) as well as the activity of HO-1. Hematin is the "X factor" required to grown Haemophilus influenzae.

Application:
Hemin is used for the following applications:
    • To study bacterial strains and growth conditions.
    • Used in short-term colony assays (the culture medium consists of hemin along with other components).
    • Cell transfections.
    It may be used in β-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.

Sophie Joly et. al. Journal of clinical microbiology, 42(3), undefined (2004-3-9)
S Abboud and D J Haile. The Journal of biological chemistry, 275(26), undefined (2000-4-5)
A Curti et. al. Journal of immunology (Baltimore, Md. : 1950), 166(2), undefined (2001-1-6)
Kim Y Fong et. al. International journal for parasitology. Drugs and drug resistance, 5(3), undefined (2015-7-8)
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