產品櫥窗
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Actinomycin D
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產品型號：101-50-76-0 商品規格： |
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Selection Antibiotics. Synonym: Actinomycin C1, Actinomycin IV, Dactinomycin
C62H86N12O16
M.W.: 1255.42
95% Min. (HPLC)
USP 23 stable substance.
Actinomycin D intercalates into DNA and thereby inhibits the transcription. It binds preferentially to guanine and blocks the RNA polymerase during the elongation step. A high dose (2ug/mL, 1.59uM) inhibits the transcription of all RNA species, lower concentrations (40ng/mL, 32nM) inhibit the synthesis of rRNA.
Actinomycin D is sold as red, shiny crystals and is soluble in acetonitrilie or acetone at 10 mg/mL and in DMSO at a minimum of 1 mg/mL. Some references also show slight solubility in water of 0.5 mg/mL.
Stock Conc.: 5 mg/mL in MeOH/EtOH
Working Conc.: 0.04-50μg/mL
M.W.: 1255.42
95% Min. (HPLC)
USP 23 stable substance.
Actinomycin D intercalates into DNA and thereby inhibits the transcription. It binds preferentially to guanine and blocks the RNA polymerase during the elongation step. A high dose (2ug/mL, 1.59uM) inhibits the transcription of all RNA species, lower concentrations (40ng/mL, 32nM) inhibit the synthesis of rRNA.
Actinomycin D is sold as red, shiny crystals and is soluble in acetonitrilie or acetone at 10 mg/mL and in DMSO at a minimum of 1 mg/mL. Some references also show slight solubility in water of 0.5 mg/mL.
Stock Conc.: 5 mg/mL in MeOH/EtOH
Working Conc.: 0.04-50μg/mL
Store at 4℃
Very toxic!
This product is hygroscopic and light-sensitive. If stored protected from light and moisture at 2-8°C, it remains unchanged, by HPLC testing, for at least 15 months. Unused dilute solutions of Actinomycin D are extremely sensitive to light and tend to adsorb to plastic and glass and should be discarded. However, frozen aliquots of concentrated stock solution are stable for at least a month.
Very toxic!
This product is hygroscopic and light-sensitive. If stored protected from light and moisture at 2-8°C, it remains unchanged, by HPLC testing, for at least 15 months. Unused dilute solutions of Actinomycin D are extremely sensitive to light and tend to adsorb to plastic and glass and should be discarded. However, frozen aliquots of concentrated stock solution are stable for at least a month.