C22H43N5O13·2H2SO4
MW: 781.76
Potency: 674-786ug/mg

Amikacin sulfate (disulfate) is a broad-spectrum aminoglycoside antibiotic derived from kanamycin A. It is effective against gram-negative bacteria such as Pseudomonas aeruginosa and a variety of enteric species. It is also effective against Mycobacterium tuberculosis. Amikacin sulfate is freely soluble in aqueous solution.

Aminoglycoside antibiotics are composed of amino groups attached to glycosides. They bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation. Consequently, protein synthesis is inhibited.

Stock conc.: 25mg/mL in ddH2O. Sterilize filtration.

Le Goffic, F., Capmau, M.L., Tangy, F., et al. Have deoxystreptamine aminoglycoside antibiotics the same binding site on bacterial ribosomes? J.Antibiot.(Tokyo) 33(8), 895-899 (1980).