產品櫥窗
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Guanosine 5′-triphosphate sodium salt hydrate, GTP
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產品型號：101-36051-31-7 商品規格： |
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Guanosine triphosphate trisodium, GTP trisodium
Formular: C10H13N5Na3O14P3
MW: 589.13
Description:
Guanosine 5′-triphosphate sodium salt hydrate is a critical nucleotide and regulator of cellular metabolism. Guanosine 5′-triphosphate sodium salt hydrate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine 5′- triphosphate sodium salt hydrate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine 5′-triphosphate sodium salt hydrate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine 5′-triphosphate sodium salt hydrate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism.
Applications：
Guanosine 5′-triphosphate sodium salt hydrate has been used:
· in the preparation of horseradish peroxidase (HRP)-modified platination reagents
· in whole cell, voltage-clamp recordings
· in in vitro inhibition of transglutaminase (tTG)
MW: 589.13
Description:
Guanosine 5′-triphosphate sodium salt hydrate is a critical nucleotide and regulator of cellular metabolism. Guanosine 5′-triphosphate sodium salt hydrate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine 5′- triphosphate sodium salt hydrate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine 5′-triphosphate sodium salt hydrate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine 5′-triphosphate sodium salt hydrate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism.
Applications：
Guanosine 5′-triphosphate sodium salt hydrate has been used:
· in the preparation of horseradish peroxidase (HRP)-modified platination reagents
· in whole cell, voltage-clamp recordings
· in in vitro inhibition of transglutaminase (tTG)
Store at -20°C