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  • Guanosine 5′-diphosphate disodium salt, GDP.2Na, >
  • 產品型號:101-7415-69-2-90

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5′-GDP-Na2

Formular: C10H13N5Na2O11P2
MW:  487.16

Description:
Guanosine 5′-diphosphate disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K+ channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). Guanosine 5'- diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400)-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Elevated levels of guanosine 5’-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI).

Application:
Guanosine 5′-diphosphate disodium salt has been used:
· in fluorescent metal nanoclusters selectivity of guanosine 3′-diphosphate-5′-di(tri)phosphate, ppGpp
· in screening of fluorescence emission of hypocrellin A-zinc complex
· as a component of assay buffers in the autoradiography of mice brain sections

Guanosine 5′-diphosphate (GDP) is used as a substrate of pyruvate kinase to produce GTP in support of RNA biosyntheis. GDP is used to study the kinetics and characteristics of GTPases such as those associated with G- protein coupled receptors (GPCR). GDP is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.
Store at -20°C