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  • Trimethoprim
  • 產品型號:101-738-70-5

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Synonym: 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine

C14H18N4O3
M.W.: 290.32
Assay: 99% Min.

A dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme. It inhibits the conversion of bacterial dihydrofolic acid to tetrahydrofolic acid which is necessary for the synthesisof amino acids, etc. and ultimately DNA synthesis. Primarily used as an antibacterial agent.

Stock conc.: 10mg/mL, in DMSO. Use immediately.

D.P. Baccanari, et al. J. Biol. Chem. 264, 1100, (1989)
N.J. Prendergast, et al. Biochemistry 28, 4645, (1989)
Store at 4℃.  Harmful