C₂₃H₂₄O₈
M.W.: 428.4
Assay:>98%
Solubility: wortmannin is Soluble in Methanol and DMSO.

Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation. It also blocks autophagosome formation and potently inhibits DNA-PK/ATM.

Store at -20℃

Handling: Hygroscopic. Protect from Light and Moisture.
Store in Tightly Sealed Vial.