C₅₁H₇₉NO₁₃
M.W. 914.2
Assay: >98%

 

Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins. Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway. Rapamycin name is derived from the native word for Easter Island, Rapi Nui.

Solubility:  
in DMSO at 200 mg/mL
in ethanol at 50 mg/mL

Working concentration:
- 10~100 nM when used as an inhibitor in the TLR signaling cascade
- 10~500 nM when used to induce autophagy

 

Merck Index., 1996., 12:, 8288., 2. Vezina, C., et al.. 
Purification and Characterization., J. Antibiot., 1975., 28:, 721., 3. Attur, M.G., R. Patel.,. 
Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production., Inflamm Res., 2000., 49(1):, 20-26.. 

 

Store at -20℃

Handling: Hygroscopic. Protect from Light and Moisture.