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  • Cyclosporin A
  • 產品型號:101-59865-13-3

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Synonym: Antibiotic S 7481F1, Cyclosporine

C62H111N11O12
M.W.: 1202.6
Assay: >99%
Soluble in Methanol, Ethanol, Acetone and Chloroform.

Cyclosporin A is used for immunosuppressive studies.
A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
Store at 4℃

Very toxic! Handling: Warning! Toxic. Wear gloves/mask when handling product. Avoid contact by all modes of exposure.