ClC6H3(NO2)2     1-Chloro-2,4-dinitrobenzene is used as a reagent for the detection and determination of pyridine compounds. It has been used as alkylating agent to evaluate the depletion of intracellular erythrocyte glutathione (GSH). It is an irreversible inhibitor of human thioredoxin reductase.
     Incompatible with strong oxidizing agents, ammonia. Reacts with hydrazine hydrate.


Elias S. J. Arner; Mikael Bjornstedt and Arne Holmgren. 1-Chloro-2,4-dinitrobenzene Is an Irreversible Inhibitor of Human Thioredoxin Reductase. Loss of thioredoxin disulfide reductase activity is accompanied by a large increase in nadph oxidase activity.Journal of Biological Chemistry.1995, 270 3479-3482.
YC Awasthi; HS Garg; DD Dao; CA Partridge and SK Srivastava. Enzymatic conjugation of erythrocyte glutathione with 1-chloro-2,4-dinitrobenzene: the fate of glutathione conjugate in erythrocytes and the effect of glutathione depletion on hemoglobin. bloodjournal.hematologylibrary.1981, 58 733-738.

Specification:

Appearance (Color):	Pale yellow to yellow to orange to black
Form:	Crystals or powder or crystalline powder or lumps or fused solid or flakes
Assay (GC):	≥98%
Identification (FTIR):	Conforms
Melting Point (clear melt):	46.0-53.0°C

 
                     
                


 

Store at Room Temp.