產品櫥窗
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Anisomycin
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產品型號：101-22862-76-6 商品規格： |
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Selection Antibiotics. Synonym: (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate, Flagecidin
C14H19NO4
M.W. 265.31
Appearance: White crystalline powder
Solubility: Clear and colorless, completely soluble in 10 mg/ml in EtOAc
Purity(HPLC): ≥98.0%
Purity(TLC): ≥99.0%
Anisomycin is a pyrrolidine antibiotic, that acts as an anti-fungal antibiotic which inhibits Protein Synthesis. Anisomycin also activates p54, MAP Kinases and Stress-Activated Protein Kinases.
Anisomycin is used in Martin-Lewis Medium to inhibit C. albicansand aid in identification of N. gonorrhoeae. Finally, Anisomycin or Flagecidin is also anti-protozoal agent.
Jerry W. Rudy, Joseph C. Biedenkapp, et al. Anisomycin and the reconsolidation hypothesis. Learn. Mem, 2006;13;1- 3.
Ann E. Power, Daniel J. Berlau, et al. Anisomycin infused into the hippocampus fails to block "reconsolidation" but impairs extinction: The role of re-exposure duration. Learn. Mem, 2006; 13: 27 - 34.
Valerie Croons, Wim Martinet, et al. The Protein Synthesis Inhibitor Anisomycin Induces Macrophage Apoptosis in Rabbit Atherosclerotic Plaques through p38 Mitogen-Activated Protein Kinase. J. Pharmacol. Exp. Ther, 2009; 329: 856 - 864.
Anisomycin is soluble at 25 mg/mL in ethanol and 50 mg/mL in DMSO. Moderately soluble in water at 2 mg/ml. For higher solubility in aqueous solution (100 mg/ml), the pH should be lowered to 5.0. It is also soluble in lower alcohols, esters, ketones, chloroform; slightly soluble in benzene, toluene and hexane.1 Sigma routinely tests the solubility at 20 mg/mL in methanol, yielding a clear, faint yellow solution.
M.W. 265.31
Appearance: White crystalline powder
Solubility: Clear and colorless, completely soluble in 10 mg/ml in EtOAc
Purity(HPLC): ≥98.0%
Purity(TLC): ≥99.0%
Anisomycin is a pyrrolidine antibiotic, that acts as an anti-fungal antibiotic which inhibits Protein Synthesis. Anisomycin also activates p54, MAP Kinases and Stress-Activated Protein Kinases.
Anisomycin is used in Martin-Lewis Medium to inhibit C. albicansand aid in identification of N. gonorrhoeae. Finally, Anisomycin or Flagecidin is also anti-protozoal agent.
Jerry W. Rudy, Joseph C. Biedenkapp, et al. Anisomycin and the reconsolidation hypothesis. Learn. Mem, 2006;13;1- 3.
Ann E. Power, Daniel J. Berlau, et al. Anisomycin infused into the hippocampus fails to block "reconsolidation" but impairs extinction: The role of re-exposure duration. Learn. Mem, 2006; 13: 27 - 34.
Valerie Croons, Wim Martinet, et al. The Protein Synthesis Inhibitor Anisomycin Induces Macrophage Apoptosis in Rabbit Atherosclerotic Plaques through p38 Mitogen-Activated Protein Kinase. J. Pharmacol. Exp. Ther, 2009; 329: 856 - 864.
Anisomycin is soluble at 25 mg/mL in ethanol and 50 mg/mL in DMSO. Moderately soluble in water at 2 mg/ml. For higher solubility in aqueous solution (100 mg/ml), the pH should be lowered to 5.0. It is also soluble in lower alcohols, esters, ketones, chloroform; slightly soluble in benzene, toluene and hexane.1 Sigma routinely tests the solubility at 20 mg/mL in methanol, yielding a clear, faint yellow solution.
Store at 4℃. Protect from light and moisture! Very toxic!
Store the product dessicated at 2-8 °C.
Under these conditions the product is stable for 4 years. Aqueous solutions of anisomycin are most stable at neutral pH. Slightly acidic solutions lose activity at relatively slow rates, while alkaline solutions lose activity more rapidly.3 DMSO solutions are stable for at least one month at 2-8 °C.
Store the product dessicated at 2-8 °C.
Under these conditions the product is stable for 4 years. Aqueous solutions of anisomycin are most stable at neutral pH. Slightly acidic solutions lose activity at relatively slow rates, while alkaline solutions lose activity more rapidly.3 DMSO solutions are stable for at least one month at 2-8 °C.